Endocrine Abstracts

Women with a history of GDM may be at increased risk for future diabetes and cardiovascular disease. The aim of this study was to investigate the endothelium dependent hemostatic factors as well as the parameters of endothelial function and inflammation in women with pGDM.Eighty women with pGDM and 40 women (control) healthy women with normal glucose tolerance during pregnancy were studied. In all women, plasma glucose, insulin, C-peptid, lipid profile, ...

Aim: In our study, in regard with the women cases of obesity, we have aimed at determining the correlation that existed among the anemia markers, insulin resistance (IR) and fact of Metabolic syndrome (MetS).Method: We have conducted our assessment 67 women who had resorted to our clinic due to their obesity complaints and were in the premenopausal and mean age 36.7±8.8 years. We have put forward the demographic data and measured the biochemical (fa...

Pregnancy is a prothrombotic condition with increased levels of several circulating coagulation factors. The aim of the present study is to investigate the effect of gestational diabetes on plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels.Plasma TAFI and PAI-1 antigen levels were measured in 26 pregnant women with gestational diabetes, 25 pregnant women with normal glucose tolerance, and age matched 24 non-pregnant women with no h...

Objective: It is well-established that hyperthyroidism of Graves disease is caused by generation of TSH-receptor stimulating autoantibodies. However, in some patients TRAB titers may be in normal levels. The rate and the burden of TRAB negative disease vary between studies. In this study, we compared the clinical and laboratory parameters of 170 patients (85 TRAB positive and 85 TRAB negative) that were diagnosed to have Graves disease in our department....

Aim: Hypoadiponectinemia is known to be associated with insulin resistance, diabetes and obesity. Since gestational diabetes is together with increased body mass index (BMI) and decreased insulin sensitivity, the evaluation of adiponectin levels in these patients is interesting. We investigated the relationship between adiponectin and glucose tolerance during pregnancy and after delivery.Materials and methods: We evaluated plasma adiponectin levels, insu...

Various abnormalities of coagulation may occur in patients with thyroid disorders and may range from subclinical laboratory abnormalities to clinically significant disturbances of coagulation. Tissue factor pathway inhibitor (TFPI) is a newly determined potent inhibitor of tissue factor dependent coagulation system. TFPI changes in various thyroid disorders has not been evaluated yet. In this study we have evaluated total TFPI (tTFPI), free TFPI (fTFPI), tissue plasminogen act...

Aim: Changes in thyroid functions, parenchymal structure and increased frequency of thyroid diseases in inflammatory bowel diseases(IBD) have been described in various studies. In the literature, studies using the data scanning method, most of which belong to the past period, stand out. In this study, we wanted to investigate the relationship between IBD and thyroid diseases in a non-retrospective study. The aim of this study is to systematically check whether there is a relat...

Objective: Acquired partial lipodystrophy (APL) is a rare disorder characterized by progressive selective fat loss. In previous studies, metabolic complications were reported to be relatively rare in APL, while they were quite common in other types of lipodystrophy syndromes. However, so far, there has been no systematic study on metabolic complications in APL.Methods: We have systematically evaluated 21 APL patients in the Turkish Lipodystrophy Study Gr...

Thyroid cancer is the most common malignancy of the endocrine system. Papillary thyroid cancer is the most common thyroid malignancy worldwide and has a good prognosis. The prevalence of follicular thyroid cancer in endemic iodine deficiency regions is higher than in regions without iodine deficiency. However, it has been observed that the incidence of follicular thyroid cancer decreases and the incidence of papillary thyroid cancer increases after iodine prophylaxis. The Our ...

Introduction: In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumour features and reduced response to somatostatin analogue treatment. AIP is a regulator of Gαi signaling, but it is not known how the biological function of the Gαi pathway is controlled.Aim: To study somatic GNAS and AIP mutation status, AIP and Gαi-2 protein expressions, Ki67 proliferation indices, and clinical parameters in p...